Proportions of CD41 memory T cells are altered in individuals chronically infected with Schistosoma haematobium
نویسندگان
چکیده
Institute of Immunology and Infection Research, Centre for Immunity, Infection and Evolution, School of Biological Sciences, Ashworth Laboratories, King’s Buildings, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK, Laboratoire d’Immunologie, et Unité Inserm 932, InsermCIC-BT507 IGR/Curie, Institut Curie, 75005 Paris, France, Center for Infection and Immunity of Lille, INSERM U 1019, CNRS UMR 8204, Univ Lille Nord de France, Institut Pasteur de Lille, 1, rue du Professeur Calmette, 59019 Lille Cedex, France, National Institute of Health Research, PO Box CY 573, Causeway, Harare, Zimbabwe, Department of Biochemistry, University of Zimbabwe, PO Box 167, Mount Pleasant, Harare, Zimbabwe.
منابع مشابه
Proportions of CD4+ memory T cells are altered in individuals chronically infected with Schistosoma haematobium
Characterisation of protective helminth acquired immunity in humans or experimental models has focused on effector responses with little work conducted on memory responses. Here we show for the first time, that human helminth infection is associated with altered proportions of the CD4+ memory T cells, with an associated alteration of T(H)1 responses. The reduced CD4+ memory T cell proportions a...
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BACKGROUND Urogenital schistosomiasis is caused by the helminth parasite Schistosoma haematobium. In high transmission areas, children acquire schistosome infection early in life with infection levels peaking in early childhood and subsequently declining in late childhood. This age-related infection profile is thought to result from the gradual development of protective acquired immunity. Age-r...
متن کاملRegulatory and Activated T Cells in Human Schistosoma haematobium Infections
Acquired immunity against helminths is characterised by a complex interplay between the effector Th1 and Th2 immune responses and it slowly manifests with age as a result of cumulative exposure to parasite antigens. Data from experimental models suggest that immunity is also influenced by regulatory T cells (Treg), but as yet studies on Treg in human schistosome infections are limited. This stu...
متن کاملT cell clones from Schistosoma haematobium infected and exposed individuals lacking distinct cytokine profiles for Th1/Th2 polarisation.
T cell clones were derived from peripheral blood mononuclear cells of Schistosoma haematobium infected and uninfected individuals living in an endemic area. The clones were stimulated with S. haematobium worm and egg antigens and purified protein derivative. Attempts were made to classify the T cell clones according to production of the cytokines IL-4, IL-5 and IFN-gamma. All the T cell clones ...
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BACKGROUND Schistosome infections are often clinically silent, but some individuals develop severe pathological reactions. In several disease processes, T-helper 17 (Th17) cells have been linked to tissue injuries, while regulatory T cells (Tregs) are thought to downmodulate inflammatory reactions. We assessed whether bladder pathology in human Schistosoma haematobium infection is related to th...
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